Initiation of Urate Lowering Therapy (ULT)

Richard Lee Meng Kam

The Singapore Family Physician

Back to issue Vol 51 No. 1 - FPSC 126 Chronic Disease Management 2025

Initiation of Urate Lowering Therapy (ULT)

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Author(s):

Richard Lee Meng Kam

Published in:

The Singapore Family Physician - Chronic Disease Management 2025

Publication date:

17 January 2025

ISSN:

0377-5305

Abstract

Gout is an inflammatory crystal arthritis characterised by hyperuricaemia and deposition of monosodium urate crystals (MSU) into joints and soft tissues. Urate-lowering therapy (ULT) is the cornerstone of long term managing chronic hyperuricemia and recurrent flares in patients with chronic tophaceous gout. Early ULT results in suppression of serum uric acid (SUA) and dissolution of deposited MSU crystals and tophi, thus preventing joint erosion complications.